反应详情

5-[4-(2-{[tert-butyl(dimethyl)silyl]oxy}ethoxy)phenyl]-3-methyl-1,3-oxazolidin-2-one (0.66 g, 1.87 mmol) and potassium hydroxide (4M aqueous solution, 1.4 mL, 5.61 mmol) dissolved in ethanol (8 mL) is refluxed for 2.5 h and then stirred at room temperature for 16 h. Reaction mixture is concentrated under reduced pressure, water (5 mL) is added and the mixture is extracted with chloroform:methanol (9:1) (5×10 mL). The combined organic layers are dried over magnesium sulfate and concentrated to provide a residual oil. This oil is triturated with ether to provide a white solid (0.28 g).

1. temperatureis refluxed for 2.5 h
2. customReaction mixture
3. concentrationis concentrated under reduced pressure, water (5 mL)
4. additionis added
5. extractionthe mixture is extracted with chloroform:methanol (9:1) (5×10 mL)
6. dry with materialThe combined organic layers are dried over magnesium sulfate
7. concentrationconcentrated
8. customto provide a residual oil
9. customThis oil is triturated with ether