Dimethylformamide → HCID 66671331, compound

Participants

Reaction Steps

4-Fluorobenzoic acid (45 mg), N-methylmorpholine (0.05 ml), hydroxybenzotriazole (51.5 mg) were added to the solution of 4-amino-1-(2-biphenyl-4-ylethyl)-2-(tert-butoxycarbonyl)butyl benzoate (150 mg) obtained from Example 3, step 2 in dry dimethylformamide (2 ml) at 0° C., 1-ethyl-3-(3′-dimethylaminopropyl)-carbodiimide (92 mg) was added and the reaction mixture was stirred overnight. The reaction mixture was taken in distilled water and extracted with ethylacetate. The organic layer was washed with distilled water and brine solution and dried over anhydrous sodium sulphate followed by evaporation under reduced pressure. The residue thus obtained was purified by column chromatography using 10% ethyl acetate in hexane as eluent to get the title compound (120 mg).

Provenance & Evidence