Tetrahydrofuran → HCID 69247048, compound

Participants

Reaction Steps

To a solution of the compound (165 mg) prepared from Step 1 above, in dry methanol and THF (1:1, 8 ml) at −20° C. was added sodium borohydride (38 mg) and the reaction mixture was stirred at rt for 3 h and then at 45° C. for 1 hour. The reaction mixture was cooled to 0° C. and quenched with saturated ammonium chloride solution. The solvents were evaporated in vacuo and the residue taken into water and extracted with ethyl acetate. The combined organic extracts were washed with water and brine and dried over anhydrous sodium sulfate. The solvent was evaporated under reduced pressure to obtain the crude title compound (165 mg).

Provenance & Evidence