反应详情

Benzyl 4-[((3R)-1-{3-[4-(methylsulfonyl)phenyl]propyl}piperidin-3-yl)methyl]piperazine-1-carboxylate (5.00 g, 9.70 mmol) was dissolved in methanol (30 ml) in a three-necked flask. The air was removed under reduced pressure and replaced with argon before the addition of 10% Pd/C (1.00 g). A balloon of hydrogen was then added and the reaction stirred at room temperature for 18 h. The hydrogen was evacuated and replaced with argon. The catalyst was then filtered using a nylon whatman autocup and the solvent removed under reduced pressure to afford the desired product as a yellow gum (3.50 g, 95% crude yield).

1. customThe air was removed under reduced pressure
2. additionreplaced with argon before the addition of 10% Pd/C (1.00 g)
3. additionA balloon of hydrogen was then added
4. customThe hydrogen was evacuated
5. filtrationThe catalyst was then filtered
6. customthe solvent removed under reduced pressure