Hydrochloric Acid → 1-[(1-Benzylpiperidin-3-yl)methyl]piperazin-2-one dihydrochloride

Participants

Reaction Steps

To a solution of tert-butyl 4-[(1-benzylpiperidin-3-yl)methyl]-3-oxopiperazine-1-carboxylate (95 mg) in dichloromethane (1 mL) was added 4M hydrochloric acid in dioxane (1 mL). The mixture was stirred at room temperature for 15 minutes and then evaporated to give the title compound as a sticky white solid (89 mg, 100%).

Provenance & Evidence