Thionyl Chloride → HCID 131711526, compound

Participants

Reaction Steps

To 11 g. of 1-ethyl-3-methyl-1H-pyrazolo-[3,4-b]pyridine-5-methanol (0.057 mol.), dissolved in 50 ml. of anhydrous benzene are added dropwise 55 ml. of thionyl chloride. A white suspension formed by this reaction is stirred for an additional three hours at room temperature. Then the slurry is sucked off, washed with benzene and dried at 70°, yield: 6.6 g. of 5-chloromethyl-1-ethyl-3-methyl-1H-pyrazolo[3,4-b]pyridine, hydrochloride (1:1); m.p. 154°-157°.

Provenance & Evidence