HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triacetoxyperiodinane → 4-Boc-1-Cbz-piperazine-2-carbaldehyde
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triacetoxyperiodinane | HCID 159087 | — |
| Reactant | 4-(1,1-Dimethylethyl) 1-(phenylmethyl) 2-(hydroxymethyl)-1,4-piperazinedicarboxylate | HCID 23531039 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 4-Boc-1-Cbz-piperazine-2-carbaldehyde | HCID 59671527 | 57.3% |
Reaction Steps
To 1-benzyl 4-tert-butyl 2-(hydroxymethyl)piperazine-1,4-dicarboxylate (0.4 g) in CH2Cl2 (10 ml) under argon was added Dess Martin periodinane (533 mg), the mixture stirred at room temperature for 16 hours, evaporated to half volume, saturated aqueous sodium bicarbonate and ethyl acetate added, the organic phase dried (MgSO4), and evaporated to give the title compound (228 mg, 57%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08710224B2 |
| Source dataset | uspto-grants-2014_04 |
| ORD ID | ord-1520dff97d0d4c9081ea84cd59d19608 |
| Source note | uspto-grants-2014_04 |