反应详情

A solution of 10 g of 5-aminosalicyclic acid, 100 ml of methanol and 5 ml of sulfuric acid are refluxed overnight. The reaction mixture is cooled, basified with sodium carbonate and the methanol is evaporated. The resulting solid is washed with water and dried giving 4.0 g of methyl-5-aminosalicylic acid.

1. temperatureThe reaction mixture is cooled
2. customthe methanol is evaporated
3. washThe resulting solid is washed with water
4. customdried