HCID 67158148, compound → HCID 57656854, compound

HRID 2371202Notes

Reaction equation

HRID 2371202 reaction equation
C(OC([N:11]1[CH2:16][CH2:15][N:14]([CH:17]2[CH2:19][CH2:18]2)[CH2:13][CH:12]1[C:20]([N:22]1[CH2:27][CH2:26][N:25]([C:28]([NH:30][C:31]2[CH:36]=[CH:35][C:34]([Cl:37])=[C:33]([Cl:38])[CH:32]=2)=[O:29])[CH2:24][CH2:23]1)=[O:21])=O)C1C=CC=CC=1.C1(N2CCC[C@H](CN3CCN(C(OCC4C=CC=CC=4)=O)CC3)C2)CC1>>[CH:17]1([N:14]2[CH2:15][CH2:16][NH:11][C@@H:12]([C:20]([N:22]3[CH2:23][CH2:24][N:25]([C:28]([NH:30][C:31]4[CH:36]=[CH:35][C:34]([Cl:37])=[C:33]([Cl:38])[CH:32]=4)=[O:29])[CH2:26][CH2:27]3)=[O:21])[CH2:13]2)[CH2:18][CH2:19]1

Participants

3

Reactant 2

HCID 67158148HCID 67158148, compoundHCID 67220711HCID 67220711, compound

Product 1

HCID 57656854HCID 57656854, compound

Procedure

The benzyl-4-cyclopropyl-2-[(4-{[(3,4-dichlorophenyl)amino]carbonyl}piperazin-1-yl)carbonyl]piperazine-1-carboxylate used in the above was prepared in a manner analogous to benzyl 4-{[(3R)-1-cyclopropylpiperidin-3-yl]methyl}piperazine-1-carboxylate.

Sources & evidence

ORD record
ord-03357502eb3f4fefa4504fb936079824
Source dataset
uspto-grants-2014_04
Patent number
US08710224B2

Reaction notes

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