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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2371207Generated: October 31, 2026

Propargyl bromide → (2R)-1-(tert-Butoxycarbonyl)-4-(2-methylprop-2-en-1-yl)piperazine-2-carboxylic acid

https://huagongshe.com/reaction/2371207

Reaction equation

Participants

RoleNameHCIDCharge
ReactantPropargyl bromideHCID 7842—
Reactant(2R)-1-(tert-butoxycarbonyl)-4-isopropylpiperazine-2-carboxylic acidHCID 51440433—
Reactant(2R)-1-(tert-Butoxycarbonyl)-4-(prop-2-yn-1-yl)piperazine-2-carboxylic acidHCID 57656800—
Product(2R)-1-(tert-Butoxycarbonyl)-4-(2-methylprop-2-en-1-yl)piperazine-2-carboxylic acidHCID 59846065—

Reaction Steps

(2R)-1-(tert-Butoxycarbonyl)-4-(prop-2-yn-1-yl)piperazine-2-carboxylic acid used in Route E1 was prepared using the procedure described for (2R)-1-(tert-butoxycarbonyl)-4-isopropylpiperazine-2-carboxylic acid above but using prop-2-ynyl bromide.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08710224B2
Source datasetuspto-grants-2014_04
ORD IDord-4aba05ff5e384411bc6ab6f1c7d22736
Source noteuspto-grants-2014_04