Methanesulfonyl chloride → HCID 57656689, compound

HRID 2371210Notes

Reaction equation

[CH3:1][S:2](Cl)(=[O:4])=[O:3].[Cl:6][C:7]1[CH:8]=[C:9]([NH:14][C:15]([N:17]2[CH2:22][CH2:21][N:20]([C:23]([C@H:25]3[CH2:30][N:29]([CH2:31][CH3:32])[CH2:28][CH2:27][NH:26]3)=[O:24])[CH2:19][CH2:18]2)=[O:16])[CH:10]=[CH:11][C:12]=1[Cl:13]>>[Cl:6][C:7]1[CH:8]=[C:9]([NH:14][C:15]([N:17]2[CH2:18][CH2:19][N:20]([C:23]([C@H:25]3[CH2:30][N:29]([CH2:31][CH3:32])[CH2:28][CH2:27][N:26]3[S:2]([CH3:1])(=[O:4])=[O:3])=[O:24])[CH2:21][CH2:22]2)=[O:16])[CH:10]=[CH:11][C:12]=1[Cl:13]

Participants

Reactant 2

HCID 31297Methanesulfonyl chloride

HCID 57656871HCID 57656871, compound

Product 1

HCID 57656689HCID 57656689, compoundYield 64%

Procedure

In this way, using methane sulphonylchloride (13 μl), N-(3,4-Dichlorophenyl)-4-{[(2R)-4-ethylpiperazin-2-yl]carbonyl}piperazine-1-carboxamide (70 mg) gave the title compound (53 mg, 64%).

Sources & evidence

ORD record: ord-69c58eb0a352465b82254c2f3e3a9349
Source dataset: uspto-grants-2014_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08710224B2

Reaction notes

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