HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → (S)-3-Allyloxy-2-amino-propionic acid methyl ester hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | (S)-3-Allyloxy-2-tert-butoxycarbonylamino-propionic acid methyl ester | HCID 57846413 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | (S)-3-Allyloxy-2-amino-propionic acid methyl ester hydrochloride | HCID 86650243 | — |
Reaction Steps
Methyl ester 37 (1.00 g, 3.86 mmol) was dissolved in 4M hydrogen chloride in 1,4-dioxane (40 mL). The resultant solution was stirred at rt for 18 h before being concentrated in vacuo to afford a white solid, 0.656 g, 87%. m.p. 87-89° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08710178B2 |
| Source dataset | uspto-grants-2014_04 |
| ORD ID | ord-572d78ed4fe04ef9901f0cc1abd2a82d |
| Source note | uspto-grants-2014_04 |