1,3,4-Thiadiazol-2-amine → Ethyl [(1,3,4-thiadiazol-2-ylamino)thioxomethyl]carbamate

Participants

Reaction Conditions

Reaction Steps

To a stirred solution of 19.2 g (190 mM) of 2-amino-1,3,4-thiadiazole in 200 ml of acetonitrile were added in one portion 25 g (190 mM) of ethoxycarbonyl isothiocyanate. The reaction mixture was stirred at 24° C for sixteen hours. The precipitate was collected by filtration, washed three times with ethyl acetate and dried to provide 35 g (80% yield) of [(1,3,4-thiadiazol-2-ylamino)thioxomethyl]carbamic acid, ethyl ester.

Provenance & Evidence