Water → HCID 23535509, compound

HRID 2371385Notes

Reaction equation

HRID 2371385 reaction equation
C(OC([N:11]1[CH2:15][C@H:14]([OH:16])[CH2:13][C@H:12]1[C:17]([N:19]([CH3:21])[CH3:20])=[O:18])=O)C1C=CC=CC=1.O.[H][H]>C(O)C.[C].[Pd]>[CH3:20][N:19]([CH3:21])[C:17]([C@@H:12]1[CH2:13][C@@H:14]([OH:16])[CH2:15][NH:11]1)=[O:18]

Participants

6

Reactant 3

HCID 962WaterHCID 16123358Phenylmethyl (2S,4R)-2-[(dimethylamino)carbonyl]-4-hydroxy-1-pyrrolidinecarboxylateHCID 178418361HCID 178418361, compound

Product 1

HCID 23535509HCID 23535509, compound

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 178418390HCID 178418390, compoundSolvent

Procedure

To a solution of (2S,4R)-1-benzyloxycarbonyl-2-dimethylaminocarbonyl-4-hydroxypyrrolidine (5.97 g) in ethanol (60 ml), 10% palladium-carbon (containing water 50 (1.20 g) was added, and the mixture was hydrogenated at room temperature for 3 hours under an atmospheric pressure of hydrogen. After removal of the catalyst by filtration, the filtrate was evaporated to remove the solvent to give (2S,4R)-2-dimethylaminocarbonyl-4-hydroxypyrrolidine.

Workup

  1. additionwas added
  2. customAfter removal of the catalyst
  3. filtrationby filtration
  4. customthe filtrate was evaporated
  5. customto remove the solvent

Sources & evidence

ORD record
ord-6b19aafa4c794a708e73d75862abea08
Source dataset
uspto-grants-1992_03
Patent number
US05093328

Reaction notes

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