Hydrochloric Acid → HCID 86745513, compound

Participants

Reaction Steps

(2S,4S)-1-Methyl-2-methylaminocarbonyl-4-acetylthiopyrrolidine (215 mg) was dissolved in methanol (2.4 ml), and a solution of sodium methoxide (54 mg) in methanol (1.2 ml) was added thereto at room temperature under nitrogen stream, followed by stirring at the same temperature for 3 minutes. To the reaction mixture, 6N hydrochloric acid (0.38 ml) was added, and the solvent was distilled off. The residue was dissolved in a mixture of dichloromethane and methanol (4:1) and dried over magnesium sulfate. Removal of the solvent gave (2S,4S)-1-methyl-2-methylaminocarbonyl4-mercaptopyrrolidine hydrochloride.

Provenance & Evidence