Hydrazine → HCID 67905363, compound

HRID 2371421Notes

Reaction equation

HRID 2371421 reaction equation
[NH2:1][NH2:2].[O:3]=[C:4]1[CH:9]([CH2:10][C:11](OC)=[O:12])[S:8](=[O:16])(=[O:15])[C:7]2[S:17][C:18]([S:20](=[O:23])(=[O:22])[NH2:21])=[CH:19][C:6]=2[NH:5]1>CO>[S:20]([C:18]1[S:17][C:7]2[S:8](=[O:16])(=[O:15])[CH:9]([CH2:10][C:11]([NH:1][NH2:2])=[O:12])[C:4](=[O:3])[NH:5][C:6]=2[CH:19]=1)(=[O:23])(=[O:22])[NH2:21]

Participants

4

Reactant 2

HCID 9321HydrazineHCID 86745510HCID 86745510, compound

Product 1

HCID 67905363HCID 67905363, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Anhydrous hydrazine (1 ml) was added to a solution of methyl (2,3-dihydro-2,4,4-trioxo-6-sulfamoyl-1H-thieno[2,3-b][1,4]thiazin-3-yl)acetate (1.0 g) in methanol (10 ml) at ambient temperature with stirring. After 5-6 hours, the methanol was removed under reduced pressure and the residue was treated with water (10 ml). The pH was adjusted to 6.5 and the resulting precipitate was collected, rinsed with water and dried under vacuum to give 0.40 g (2,3-dihydro-6-sulfamoyl-2,4,4-trioxo-1H-thieno[2,3-b][1,4]thiazin-3-yl)acetic acid hydrazide, mp 230° C., dec.

Workup

  1. customthe methanol was removed under reduced pressure
  2. additionthe residue was treated with water (10 ml)
  3. customthe resulting precipitate was collected
  4. washrinsed with water
  5. customdried under vacuum

Sources & evidence

ORD record
ord-17f5911b7ee34a7c88cb981e686592f3
Source dataset
uspto-grants-1992_03
Patent number
US05093332

Reaction notes

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