Phosphoric Acid → HCID 15670957, compound

Participants

Reaction Steps

6-hydroxyquinoline-2-one (481 mg) and orthophosphoric acid (0.55 ml) were dissolved in 5 ml of benzene, and then a solution of 0.55 ml of isoprene in 5 ml of benzene was added thereto with stirring. The resulting mixture was heated under reflux for 30 minutes. The reaction liquid was poured into ice-cold water and extracted with ethyl acetate. The extracted liquor was washed with water, dehydrated by addition of anhydrous sodium sulfate and filtered. The solvent in the filtrate was distilled away under reduced pressure, and the resulting residue was recrystallized from ethanol to give 567 mg of pale yellow needle-like crystals.

Provenance & Evidence