Triisopropyl phosphite → HCID 13464942, compound

Participants

Reaction Conditions

Reaction Steps

Methyl bromofluoroacetate (17.1q) was mixed with triisopropyl phosphite (41.6 g) and heated with stirring at 150° C. Samples were withdrawn at intervals and analysed by GLC. After 5.5 hours, all of the initial ester had been consumed. The mixture was cooled to the ambient temperature, and excess triisopropyl phosphite was removed by distillation at reduced pressure (52° C./1.5 mm Hg). The straw-coloured residue (19.7 g was identified as substantially pure methyl diisopropylphosphonofluoroacetate.

Provenance & Evidence