(R)-camphorsulfonic acid → HCID 86745525, compound

Participants

Reaction Steps

The amine intermediate from Step 2 was heated to 50° C. in methanol (20 mL) containing (1R)-(-)-10-camphorsulfonic acid (200 mg) for 18 hours. After quenching with brine the mixture was extracted with ether (100 mL). The crude material was chromatographed on silica gel eluting with a 1:5 mixture of ethyl acetate-hexane to collect the least polar of the two main components of the mixture. This afforded the title compound as a yellow filmy residue which was taken into the next step.

Provenance & Evidence