Methyl iodide → N,N,N-Trimethyl-4-phenylbutan-1-aminium iodide

HRID 2371528Notes

Reaction equation

HRID 2371528 reaction equation
[CH3:1][N:2]([CH2:4][CH2:5][CH2:6][CH2:7][C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)[CH3:3].[CH3:14][I:15]>CO>[I-:15].[CH3:1][N+:2]([CH2:4][CH2:5][CH2:6][CH2:7][C:8]1[CH:9]=[CH:10][CH:11]=[CH:12][CH:13]=1)([CH3:14])[CH3:3]

Participants

4

Reactant 2

HCID 6328Methyl iodideHCID 135467464-PHENYL-N,N-DIMETHYLBUTYLAMINE

Product 1

HCID 43505N,N,N-Trimethyl-4-phenylbutan-1-aminium iodide

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a solution of 287 mg of N,N-dimethyl-4-phenylbutylamine in 3 ml of absolute methanol, 505 μl of methyl iodide was added at a room temperature with stirring, and the mixture was stirred at a room temperature for 6.5 hours. The reaction mixture was concentrated under a reduced pressure, and after adding ethyl acetate allowed to stand for formation of crystal. The crystal was filtered, washed with ethyl acetate, and dried under a reduced pressure to obtain 439 mg of the title compound as a colorless crystal.

Workup

  1. stirringthe mixture was stirred at a room temperature for 6.5 hours
  2. concentrationThe reaction mixture was concentrated under a reduced pressure
  3. additionafter adding ethyl acetate
  4. filtrationThe crystal was filtered
  5. washwashed with ethyl acetate
  6. customdried under a reduced pressure

Sources & evidence

ORD record
ord-964d41e7070c4735a4c768d94607c276
Source dataset
uspto-grants-1992_03
Patent number
US05093370

Reaction notes

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