HCID 19907389, compound → HCID 19907339, compound

Participants

Reaction Steps

To a solution of 3.5 g of 1,4-bis(4-dimethylaminobutyl)-2-nitrobenzene in 120 ml of methanol, 9 ml of 6N hydrochloric acid and 1.5 g of 5% palladium/carbon were added. The catalytic reduction was carried out under an atmospheric pressure and at a room temperature. When about 710 ml of hydrogen was absorbed after one hour, the reaction was terminated, and the reaction mixture was filtered to remove the catalyst and evaporated under a reduced pressure. After adding chloroform, the mixture was again evaporated under a reduced pressure. The residue was alkalized with 10% sodium hydroxide, subjected to salting out and extracted twice with 50 ml of chloroform. The extract was washed with water and a saturated sodium chloride aqueous solution and dried over magnesium sulfate. The solvent was removed under a reduced pressure to obtain 2.7 g of the title compound as a pale brown liquid.

Provenance & Evidence