Acetic Anhydride → HCID 19907388, compound

HRID 2371545Notes

Reaction equation

HRID 2371545 reaction equation
C(O[C:5](=[O:7])[CH3:6])(=O)C.[NH2:8][C:9]1[CH:14]=[C:13]([CH2:15][CH2:16][CH2:17][CH2:18][N:19]([CH3:21])[CH3:20])[CH:12]=[CH:11][C:10]=1[CH2:22][CH2:23][CH2:24][CH2:25][N:26]([CH3:28])[CH3:27].C(=O)([O-])[O-].[Na+].[Na+].[OH-].[Na+]>>[C:5]([NH:8][C:9]1[CH:14]=[C:13]([CH2:15][CH2:16][CH2:17][CH2:18][N:19]([CH3:21])[CH3:20])[CH:12]=[CH:11][C:10]=1[CH2:22][CH2:23][CH2:24][CH2:25][N:26]([CH3:28])[CH3:27])(=[O:7])[CH3:6]

Participants

5

Reactant 4

HCID 7918Acetic AnhydrideHCID 10340Sodium CarbonateHCID 14798Sodium HydroxideHCID 19907339HCID 19907339, compound

Product 1

HCID 19907388HCID 19907388, compound

Conditions

Temperature
50 °C

Procedure

To 1 ml of acetic anhydride was added 0.58 g of 2-amino-1,4-bis(4-dimethylaminobutyl)benzene, and the solution was stirred at 50° C. for 2.5 hours. After adding 8 ml of 5% sodium carbonate, the mixture was stirred at a room temperature for 5 hours, alkalized with 10% sodium hydroxide, subjected to salting out and extracted with total 70 ml of chloroform. The extract was washed with a saturated sodium chloride aqueous solution, dried over potassium carbonate, and evaporated under a reduced pressure to obtain 0.56 g of the title compound as a pale brown crystal.

Workup

  1. stirringthe mixture was stirred at a room temperature for 5 hours
  2. extractionextracted with total 70 ml of chloroform
  3. washThe extract was washed with a saturated sodium chloride aqueous solution
  4. dry with materialdried over potassium carbonate
  5. customevaporated under a reduced pressure

Sources & evidence

ORD record
ord-b091b6e9fe744528bcab0b377b419134
Source dataset
uspto-grants-1992_03
Patent number
US05093370

Reaction notes

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