Sodium Hydroxide → HCID 13016028, compound

Participants

Reaction Steps

To a solution of 2.01 g lithium aluminium hydride in 24 ml of tetrahydrofuran was added dropwise a solution of 7.04 g aluminium chloride in 36 ml of ethyl ether at a room temperature for 10 minutes, and after stirring for 10 minutes, a solution of 5.09 g 1,4-bis(3-cyanopropyl)benzene in 48 ml of tetrahydrofuran was added dropwise over 30 minutes, and the mixture was stirred for 5 hours. To the reaction mixture were successively added 2.0 ml of water, 15% sodium hydroxide aqueous solution and a solution of 6.34 g of sodium hydroxide in 6 ml of water. The mixture was stirred for 30 minutes, filtered to remove impurity and washed with tetrahydrofuran. The washed filtrate was concentrated under a reduced pressure, codistilled twice with tetrahydrofuran and twice with chloroform, and dried under a reduced pressure to obtain 5.36 g of 1,4-bis(4-aminobutyl)benzene as yellow liquid.

Provenance & Evidence