HCID 53940848, compound → 4-Methoxyphenol

HRID 2371579Notes

Reaction equation

HRID 2371579 reaction equation
C(O[CH2:7][CH:8](O)[CH2:9][O:10][C:11](=O)C=NOC)(=O)C(C)=C.[C:18](OCCC(OC(=O)C=NOC)O)(=[O:22])[C:19](C)=[CH2:20]>C(Cl)(Cl)Cl>[CH3:11][O:10][C:9]1[CH:8]=[CH:7][C:18]([OH:22])=[CH:19][CH:20]=1

Participants

4

Reactant 2

HCID 53940848HCID 53940848, compoundHCID 86745531HCID 86745531, compound

Product 1

HCID 90154-Methoxyphenol

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

In this way a milky suspension is obtained which is washed twice with 136 g of dichloromethane, then the chloromethylenic phases are reunited, dried over anhydrous magnesium sulphate and finally concentrated under vacuum. In this way 7.5 g of a yellow oil is isolated which is purified by preparative chromatography on a column (500×25) filled with silica of a size grading of 10 micrometers, eluting with a hexane-ethyl acetate mixture 8/2 by volume, which allows the isolation on the one hand of, 5 g (20.4 mmoles) of 1-methacryloyloxy-3-methoxyiminoacetoxy-2-propanol, and on the other hand of, 2 g (8.15 mmoles) of 3-methacryloyloxy-2-methoxyiminoacetoxy-1-propanol characterised by their NMR1H spectra registered in deuterized chloroform.

Workup

  1. customis purified by preparative chromatography on a column (500×25)
  2. additionfilled with silica of a size grading of 10 micrometers
  3. washeluting with a hexane-ethyl acetate mixture 8/2 by volume, which

Sources & evidence

ORD record
ord-7e5c1a234e894d60afa8e388d5d838d0
Source dataset
uspto-grants-1992_03
Patent number
US05093518

Reaction notes

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