Water → Hexamethyldisiloxane

Participants

Reaction Steps

A solution of the alcohol 18 (200 mg) and N-(trimethylsilyl)imidazole (0.714 ml) in dichloromethane (13 ml) is stirred at room temperature for 16 hours. After water (4.9 ml) has been added, the mixture is left stirring for 20 minutes. The mixture is then extracted with ethyl acetate. The organic phases are washed with brine and dried. After concentration under vacuum, the residue is purified by chromatography on silica gel (230-400 mesh) (12% diethyl ether in hexane), to give 200 mg of derivative 15b (80% yield).

Provenance & Evidence