diethyl 3,4-dihydro-7-[3-(4-chlorophenoxy)propoxy]-4-oxo-8-propyl-2H-1-benzopyran-2,2-dipropanoate → 3,4-dihydro-7-[3-(2-naphthalenyloxy)propoxy]-4-oxo-8-propyl-2H-1-benzopyran-2,2-dipropanoic acid

HRID 2371617Notes

Reaction equation

HRID 2371617 reaction equation
[CH:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][C:2]=1[O:11][CH2:12][CH2:13][CH2:14][O:15][C:16]1[CH:40]=[CH:39][C:19]2[C:20](=[O:38])[CH2:21][C:22]([CH2:31][CH2:32][C:33]([O:35]CC)=[O:34])([CH2:24][CH2:25][C:26]([O:28]CC)=[O:27])[O:23][C:18]=2[C:17]=1[CH2:41][CH2:42][CH3:43].ClC1C=CC(OCCCOC2C=CC3C(=O)CC(CCC(OCC)=O)(CCC(OCC)=O)OC=3C=2CCC)=CC=1>>[CH:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][C:2]=1[O:11][CH2:12][CH2:13][CH2:14][O:15][C:16]1[CH:40]=[CH:39][C:19]2[C:20](=[O:38])[CH2:21][C:22]([CH2:31][CH2:32][C:33]([OH:35])=[O:34])([CH2:24][CH2:25][C:26]([OH:28])=[O:27])[O:23][C:18]=2[C:17]=1[CH2:41][CH2:42][CH3:43]

Participants

3

Reactant 2

HCID 15157438diethyl 3,4-dihydro-7-[3-(4-chlorophenoxy)propoxy]-4-oxo-8-propyl-2H-1-benzopyran-2,2-dipropanoateHCID 15157440diethyl 3,4-dihydro-7-[3-(2-naphthalenyloxy)propoxy]-4-oxo-8-propyl-2H-1-benzopyran-2,2-dipropanoate

Product 1

HCID 151574413,4-dihydro-7-[3-(2-naphthalenyloxy)propoxy]-4-oxo-8-propyl-2H-1-benzopyran-2,2-dipropanoic acid

Procedure

The title compound was prepared by the method of Example 22 substituting 539 mg of the title product of Example 23 for the title product of Example 21. Crystallization from 5:1 ethyl acetate:hexane yielded 303 mg, m.p. 157.5°-158° C.

Workup

  1. customCrystallization from 5:1 ethyl acetate
  2. customhexane yielded 303 mg, m.p. 157.5°-158° C.

Sources & evidence

ORD record
ord-ebc8068358ea4281b15d669e47003514
Source dataset
uspto-grants-1992_03
Patent number
US05093353

Reaction notes

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