diethyl 3,4-dihydro-7-[3-(4-chlorophenoxy)propoxy]-4-oxo-8-propyl-2H-1-benzopyran-2,2-dipropanoate → 3,4-dihydro-4-oxo-7-(3-phenoxypropoxy)-2H-1-benzopyran-2,2-dipropanoic acid

HRID 2371619Notes

Reaction equation

HRID 2371619 reaction equation
[O:1]=[C:2]1[C:7]2[CH:8]=[CH:9][C:10]([O:12][CH2:13][CH2:14][CH2:15][O:16][C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=3)=[CH:11][C:6]=2[O:5][C:4]([CH2:30][CH2:31][C:32]([O:34]CC)=[O:33])([CH2:23][CH2:24][C:25]([O:27]CC)=[O:26])[CH2:3]1.ClC1C=CC(OCCCOC2C=CC3C(=O)CC(CCC(OCC)=O)(CCC(OCC)=O)OC=3C=2CCC)=CC=1>>[O:1]=[C:2]1[C:7]2[CH:8]=[CH:9][C:10]([O:12][CH2:13][CH2:14][CH2:15][O:16][C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=3)=[CH:11][C:6]=2[O:5][C:4]([CH2:23][CH2:24][C:25]([OH:27])=[O:26])([CH2:30][CH2:31][C:32]([OH:34])=[O:33])[CH2:3]1

Participants

3

Reactant 2

HCID 15157438diethyl 3,4-dihydro-7-[3-(4-chlorophenoxy)propoxy]-4-oxo-8-propyl-2H-1-benzopyran-2,2-dipropanoateHCID 15157443diethyl 3,4-dihydro-4-oxo-7-(3-phenoxypropoxyl)-2H-1-benzopyran-2,2-dipropanoate

Product 1

HCID 151574443,4-dihydro-4-oxo-7-(3-phenoxypropoxy)-2H-1-benzopyran-2,2-dipropanoic acid

Procedure

The title compound was prepared by the method of Example 22 substituting the title product of Example 26 for the title product of Example 21. Crystallization from 60% by volume ethyl acetate/hexane yielded 219 mg, m.p. 132°-133° C.

Workup

  1. customCrystallization from 60% by volume ethyl acetate/hexane
  2. customyielded 219 mg, m.p. 132°-133° C.

Sources & evidence

ORD record
ord-78de87d996f14ec4913e4a4f61a44440
Source dataset
uspto-grants-1992_03
Patent number
US05093353

Reaction notes

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