diethyl 3,4-dihydro-7-[3-(4-chlorophenoxy)propoxy]-4-oxo-8-propyl-2H-1-benzopyran-2,2-dipropanoate → 3,4-dihydro-7-[3-(1-naphthalenyloxy)propoxy]-4-oxo-8-propyl-2H-1-benzopyran-2,2-dipropanoic acid

HRID 2371620Notes

Reaction equation

HRID 2371620 reaction equation
[C:1]1([O:11][CH2:12][CH2:13][CH2:14][O:15][C:16]2[CH:40]=[CH:39][C:19]3[C:20](=[O:38])[CH2:21][C:22]([CH2:31][CH2:32][C:33]([O:35]CC)=[O:34])([CH2:24][CH2:25][C:26]([O:28]CC)=[O:27])[O:23][C:18]=3[C:17]=2[CH2:41][CH2:42][CH3:43])[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][CH:2]=1.ClC1C=CC(OCCCOC2C=CC3C(=O)CC(CCC(OCC)=O)(CCC(OCC)=O)OC=3C=2CCC)=CC=1>>[C:1]1([O:11][CH2:12][CH2:13][CH2:14][O:15][C:16]2[CH:40]=[CH:39][C:19]3[C:20](=[O:38])[CH2:21][C:22]([CH2:24][CH2:25][C:26]([OH:28])=[O:27])([CH2:31][CH2:32][C:33]([OH:35])=[O:34])[O:23][C:18]=3[C:17]=2[CH2:41][CH2:42][CH3:43])[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][CH:2]=1

Participants

3

Reactant 2

HCID 15157438diethyl 3,4-dihydro-7-[3-(4-chlorophenoxy)propoxy]-4-oxo-8-propyl-2H-1-benzopyran-2,2-dipropanoateHCID 15157445diethyl 3,4-dihydro-7-[3-(1-naphthalenyloxy)propoxy]-4-oxo-8-propyl-2H-1-benzopyran-2,2-dipropanoate

Product 1

HCID 151574463,4-dihydro-7-[3-(1-naphthalenyloxy)propoxy]-4-oxo-8-propyl-2H-1-benzopyran-2,2-dipropanoic acid

Procedure

The title compound was prepared by the method of Example 22 substituting the title product of Example 28 (549 mg) for the title product of Example 21 to give, after crystallization from ethyl acetate, 141 mg, m.p. 164°-167° C.

Workup

  1. customto give
  2. customafter crystallization from ethyl acetate, 141 mg, m.p. 164°-167° C.

Sources & evidence

ORD record
ord-de0a6ef3ec794bab90e036b852f25384
Source dataset
uspto-grants-1992_03
Patent number
US05093353

Reaction notes

Loading…