diethyl 3,4-dihydro-7-[3-(4-chlorophenoxy)propoxy]-4-oxo-8-propyl-2H-1-benzopyran-2,2-dipropanoate → 7-[3-[(4-chloro-1-naphthalenyl)oxy]propoxy]-3,4-dihydro-4-oxo-8-propyl-2H-1-benzopyran-2,2-dipropanoic acid

HRID 2371621Notes

Reaction equation

HRID 2371621 reaction equation
[Cl:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[C:5]([O:12][CH2:13][CH2:14][CH2:15][O:16][C:17]2[CH:41]=[CH:40][C:20]3[C:21](=[O:39])[CH2:22][C:23]([CH2:32][CH2:33][C:34]([O:36]CC)=[O:35])([CH2:25][CH2:26][C:27]([O:29]CC)=[O:28])[O:24][C:19]=3[C:18]=2[CH2:42][CH2:43][CH3:44])=[CH:4][CH:3]=1.ClC1C=CC(OCCCOC2C=CC3C(=O)CC(CCC(OCC)=O)(CCC(OCC)=O)OC=3C=2CCC)=CC=1>C(OCC)C>[Cl:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[C:5]([O:12][CH2:13][CH2:14][CH2:15][O:16][C:17]2[CH:41]=[CH:40][C:20]3[C:21](=[O:39])[CH2:22][C:23]([CH2:32][CH2:33][C:34]([OH:36])=[O:35])([CH2:25][CH2:26][C:27]([OH:29])=[O:28])[O:24][C:19]=3[C:18]=2[CH2:42][CH2:43][CH3:44])=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 15157438diethyl 3,4-dihydro-7-[3-(4-chlorophenoxy)propoxy]-4-oxo-8-propyl-2H-1-benzopyran-2,2-dipropanoateHCID 15157451diethyl 7-[3-[(4-chloro-1-naphthalenyl)oxy]propoxy]-3,4-dihydro-4-oxo-8-propyl-2H-1-benzopyran-2,2-dipropanoate

Product 1

HCID 151574527-[3-[(4-chloro-1-naphthalenyl)oxy]propoxy]-3,4-dihydro-4-oxo-8-propyl-2H-1-benzopyran-2,2-dipropanoic acid

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

The title compound was prepared by the method of Example 22 substituting the title product of Example 34 (515 mg) for the title product of Example 21 to give, after trituration with diethylether, 352 mg as a solid, m.p. 170.5°-171° C.

Workup

  1. customto give

Sources & evidence

ORD record
ord-056992e92e1f43abbdec47f98d07f01f
Source dataset
uspto-grants-1992_03
Patent number
US05093353

Reaction notes

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