反应详情

The title product of Example 1 (4.19 g, 10.3 mmol) was dissolved in 50 ml of acetic acid, and then hydrogenated at 70° C. using 60 psi of hydrogen and 10% palladium on carbon as catalyst. After eight hours, the mixture was allowed to cool, and insolubles were removed by filtration. The filtrate was concentrated under reduced pressure. The residue was chromatographed on silicagel column. Elution with 20% ethyl acetate/hexane afforded the title compound (0.80 g).

1. customhydrogenated at 70° C.
2. temperatureto cool
3. custominsolubles were removed by filtration
4. concentrationThe filtrate was concentrated under reduced pressure
5. customThe residue was chromatographed on silicagel column
6. washElution with 20% ethyl acetate/hexane