diethyl 3,4-dihydro-7-[3-(4-chlorophenoxy)propoxy]-4-oxo-8-propyl-2H-1-benzopyran-2,2-dipropanoate → 3,4-dihydro-7-(3-phenoxypropoxy)-8-propyl-2H-1-benzopyran-2,2-dipropanoic acid

HRID 2371637Notes

Reaction equation

HRID 2371637 reaction equation
[O:1]([CH2:8][CH2:9][CH2:10][O:11][C:12]1[CH:35]=[CH:34][C:15]2[CH2:16][CH2:17][C:18]([CH2:27][CH2:28][C:29]([O:31]CC)=[O:30])([CH2:20][CH2:21][C:22]([O:24]CC)=[O:23])[O:19][C:14]=2[C:13]=1[CH2:36][CH2:37][CH3:38])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.ClC1C=CC(OCCCOC2C=CC3C(=O)CC(CCC(OCC)=O)(CCC(OCC)=O)OC=3C=2CCC)=CC=1>>[O:1]([CH2:8][CH2:9][CH2:10][O:11][C:12]1[CH:35]=[CH:34][C:15]2[CH2:16][CH2:17][C:18]([CH2:27][CH2:28][C:29]([OH:31])=[O:30])([CH2:20][CH2:21][C:22]([OH:24])=[O:23])[O:19][C:14]=2[C:13]=1[CH2:36][CH2:37][CH3:38])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 15157438diethyl 3,4-dihydro-7-[3-(4-chlorophenoxy)propoxy]-4-oxo-8-propyl-2H-1-benzopyran-2,2-dipropanoateHCID 15157492diethyl 3,4-dihydro-7-(3-phenoxypropoxy)-8-propyl-2H-1-benzopyran-2,2-dipropanoate

Product 1

HCID 151574933,4-dihydro-7-(3-phenoxypropoxy)-8-propyl-2H-1-benzopyran-2,2-dipropanoic acidYield 94.3%

Procedure

The title compound (118 mg), m.p. 130.5°-132.5° C., was prepared by the method of Example 22 substituting the title product of Example 55 (140 mg) for the title product of Example 21.

Sources & evidence

ORD record
ord-74ab0c23779e4214bf6bf85055a84eaa
Source dataset
uspto-grants-1992_03
Patent number
US05093353

Reaction notes

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