Sodium Hydroxide → HCID 9841126, compound

Participants

Reaction Steps

A mixture of 5.30 g of ethyl 4-(5H-dibenzo[a,d]cyclohepten-5-ylidene)-1-piperidinepropionate hydrochloride, 19.3 ml of 2N sodium hydroxide aqueous solution and 30 ml of methanol was refluxed for 1 hr and concentrated. Water was added to the residue, washed with ethyl acetate and adjusted to pH 4 to 5 with 10% hydrochloric acid. The precipitate was collected by filtration to give 4.47 g of pale yellow crystals, which were recrystallized from a mixture of water and N,N-dimethylformamide to give 4.23 g of pale yellow needles, mp 201°-203° C.

Provenance & Evidence