Sodium Hydroxide → 4-(Dibenz[b,e]oxepin-11(6H)-ylidene)-1-piperidinepropionic acid

Participants

Reaction Steps

A mixture of 3.70 g of ethyl 4-(dibenz[b,e]oxepin-11(6H)-ylidene)-1-piperidinepropionate, 9.9 ml of 2N sodium hydroxide aqueous solution and 40 ml of methanol was refluxed for 30 min and concentrated. Water was added to the residue, adjusted to pH 3 with 10% hydrochloric acid. The precipitate was collected by filtration and washed with water and ether to give 3.30 g of pale yellow crystals, which were recrystallized from a mixture of water and N,N-dimethylformamide to give 2.75 g of pale yellow crystals, mp 142°-143° C.

Provenance & Evidence