反应详情

The oxalic acid salt of 3-[4-(trifluoromethyl)phenoxy]azetidine, weighing 13.0 g (0.042 mole), was partitioned between 50 ml of benzene and 50 ml of potassium hydroxide solution. The benzene layer was dried with Drierite and filtered, and to this stirring filtrate was added 2.6 g (0.046 mole) of methyl isocyanate. Stirring was continued overnight. The mixture was concentrated in vacuo, and the solid residue was recrystallized from a mixture of isopropyl ether-ethyl acetate to give 7.5 g (65%), mp 154°-157°.

1. customwas partitioned between 50 ml of benzene and 50 ml of potassium hydroxide solution
2. dry with materialThe benzene layer was dried with Drierite
3. filtrationfiltered
4. concentrationThe mixture was concentrated in vacuo
5. customthe solid residue was recrystallized from a mixture of isopropyl ether-ethyl acetate
6. customto give 7.5 g (65%), mp 154°-157°