Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
2-Methylbenzenesulfonamide → 4-[7-(2-Ethylbutylcarbamoyl)naphth-1-ylmethyl]-3-methoxy-N-(2-methylphenylsulfonyl)benzamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 2-Methylbenzenesulfonamide | HCID 6924 | — |
| 반응물 | 1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride | HCID 2723939 | — |
| 반응물 | 4-[7-(2-Ethylbutylcarbamoyl)naphth-1-ylmethyl]-3-methoxybenzoic acid | HCID 19906369 | — |
| 촉매 | 4-(Dimethylamino)pyridine | HCID 14284 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | 4-[7-(2-Ethylbutylcarbamoyl)naphth-1-ylmethyl]-3-methoxy-N-(2-methylphenylsulfonyl)benzamide | HCID 19906392 | 70% |
반응 단계
A mixture of 4-[7-(2-ethylbutylcarbamoyl)naphth-1-ylmethyl]-3-methoxybenzoic acid (189 mg), 4-dimethylaminopyridine (110 mg), 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (172 mg), and o-toluenesulfonamide (96 mg) in methylene chloride (2 ml) was stirred for 18 h. Methylene chloride (25 ml) was added, and the solution was washed (1N hydrochloric acid, brine), dried (MgSO4) and evaporated. The residue was recrystallized from 21 ml of 1:0.5:1 methylene chloride:methanol:hexane, ground to a powder and vacuum dried at 100° C. to give the title compound (179 mg, 70%) as a colorless solid; mp 126.0°-128.0° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05095038 |
| 출처 데이터셋 | uspto-grants-1992_03 |
| ORD ID | ord-3be7c6496fb94d648eacc92bff9b613d |
| 출처 메모 | uspto-grants-1992_03 |