Trifluoroacetic acid → HCID 19906402, compound

Participants

Reaction Steps

Trifluoroacetic acid (25 ml) was added to a 0° C. solution of methyl E-4-[7-[2-(t-butoxycarbonyl)prop-1-enyl]naphth-1-ylmethyl]-3-methoxybenzoate (6.43 g) in methylene chloride (50 ml). After stirring for 4 hours, the solvent was evaporated without heating. The residue was triturated with ether and the colorless solid filtered. The filtrate was concentrated and hexane was added to give another crop of product as a pale yellow solid. The two crops were combined and dried to give methyl E-4-[7-(2-carboxyprop-1-enyl)naphth-1-ylmethyl]-3-methoxybenzoate (4.43 g, 94%); mp 187.0°-187.5° C.; MS(EI), m/e=390(M+.).

Provenance & Evidence