Benzenesulfonamide → HCID 19906410, compound

HRID 2371804Notes

Reaction equation

[CH2:1]([NH:4][C:5]([CH:7]([CH3:31])[CH2:8][C:9]1[CH:18]=[C:17]2[C:12]([CH:13]=[CH:14][CH:15]=[C:16]2[CH2:19][C:20]2[CH:28]=[CH:27][C:23]([C:24](O)=[O:25])=[CH:22][C:21]=2[O:29][CH3:30])=[CH:11][CH:10]=1)=[O:6])[CH2:2][CH3:3].[C:32]1([S:38]([NH2:41])(=[O:40])=[O:39])[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=1>>[CH3:30][O:29][C:21]1[CH:22]=[C:23]([CH:27]=[CH:28][C:20]=1[CH2:19][C:16]1[C:17]2[C:12](=[CH:11][CH:10]=[C:9]([CH2:8][CH:7]([C:5](=[O:6])[NH:4][CH2:1][CH2:2][CH3:3])[CH3:31])[CH:18]=2)[CH:13]=[CH:14][CH:15]=1)[C:24]([NH:41][S:38]([C:32]1[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=1)(=[O:40])=[O:39])=[O:25]

Participants

Reactant 2

HCID 7370Benzenesulfonamide

HCID 19906379HCID 19906379, compound

Product 1

HCID 19906410HCID 19906410, compound

Procedure

Using a similar procedure to that described in Example 2.h., except starting from 4-[7-[2-(propylcarbamoyl)propyl]naphth-1-ylmethyl]-3-methoxybenzoic acid and benzenesulfonamide, the title compound was obtained (83%) as a colorless solid; mp 214.0°-217.5° C., MS(CI), m/e=559(M+H).

Sources & evidence

ORD record: ord-df98d3d9cf8e4f02ad0ac2d8ea38e384
Source dataset: uspto-grants-1992_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05095038

Reaction notes

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