HCID 19906366, compound → HCID 19906359, compound

Participants

Reaction Steps

A mixture of methyl E-4-[7-(3-carboxyprop-1-enyl)naphth-1-ylmethyl]-3-methoxybenzoate and methyl 4-[7-(2,3,4,5-tetrahydro-5-oxofuran-2-yl)naphth-1-ylmethyl]-3-methoxybenzoate (2.52 g), ethyl acetate (70 ml) and 10% (w/w) palladium on carbon (0.25 g) was hydrogenated under atmospheric pressure for 18 h. The reaction mixture was filtered through diatomaceous earth with ethyl acetate wash. The filtrate was evaporated to give methyl 4-[7-(3-carboxypropyl)naphth-1-ylmethyl]-3-methoxybenzoate (2.42 g, 96%) as a yellow foam; MS(CI), m/e=392(M+H).

Provenance & Evidence