Triethylsilane → (E)-3-[(2S,4S)-N-Allyloxycarbonyl-4-mercaptopyrrolidin-2-yl]-N,N-dimethylacrylamide

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Reaction Steps

The same operation as in Reference Example 4-2) was carried out by using (E)-3-[(2S,4S)-N-allyloxycarbonyl-4-tritylthiopyrrolidin-2-yl]-N,N-dimethylacrylamide (the compound obtained in Reference Example 6-1); 2.02 g, 3.84 mmol) and triethylsilane (0.64 ml, 4.03 mmol), followed by flash column chromatographic purification on silica gel (Wakogel® C-300, 40 ml, elution with acetone-methylene chloride 1:1) to give the title compound (980 mg, 89.9% yield).

Provenance & Evidence