Triethylsilane → (2S,4S)-N-Allyloxycarbonyl-2-[(E)-2-[4-(allyloxycarbonyl)piperazinvlcarbonyl]vinyl]-4-mercaptopyrrolidine

Participants

Reaction Steps

The same operation as in Reference Example 4-2) was carried out by using (2S,4S)-N-allyloxycarbonyl-2-[(E)-2-[4-(allyloxycarbonyl)piperazinylcarbonyl]vinyl]-4-tritylthiopyrrolidine (the compound obtained in Reference Example 8-1); 1.97 g, 3.02 mmol) and triethylsilane (0.51 ml, 3.17 mmol), followed by flash column chromatographic purification on silica gel (Wakogel® C-300, 40 ml, elution with acetone-ethyl acetate 1:2) to give the title compound (1.24 g, 100% yield) as an oil.

Provenance & Evidence