HCID 67905951, compound → HCID 22842818, compound

Participants

Reaction Steps

To a solution of benzyl N-(benzyloxycarbonyl-3-(S)-amino-2-(R)-fluorobutanoyl)glycinate (8.50 g, 21.1 mmol) in 200 mL of methanol is added 850 mg of 10% palladium on carbon. The mixture is connected to a Parr hydrogenation apparatus and hydrogenated at 50 psi for 18 hours. The mixture is then filtered through celite to remove the catalyst. Evaporation of the solvent leaves 3.66 g of the desired product as a white solid.

Provenance & Evidence