Hydrogen Bromide → HCID 19905290, compound

Participants

Reaction Conditions

Reaction Steps

A mixture containing 8.28 g (0.06 mol) of 4-fluoroacetophenone, 11.05 g (0.06 mol) of tetrahydro-1,3-thiazine hydrobromide, 2.70 g (0.09 mol) of paraformaldehyde, 25 ml ethanol and 0.1 ml of 48% hydrobromic acid is heated under reflux while stirring. After one hour an additional amount of 1.8 g (0.06 mol) of paraformaldehyde is portionwise added, the reaction mixture is heated for an additional 2 hours and then 80 ml of acetone are added. The mixture is cooled at -5° C. to give 12.73 g of product which is recrystallized from methanol to obtain 9.02 g (45.0%) of glistening crystalline hydrobromide of the title compound, m.p.: 210°-203° C.

Provenance & Evidence