HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Piperidinecarboxamide → 1-Benzylpiperidine-4-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Piperidinecarboxamide | HCID 3772 | — |
| Reactant | Benzyl Bromide | HCID 7498 | — |
| Reactant | Sodium Bicarbonate | HCID 516892 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | 1-Benzylpiperidine-4-carboxamide | HCID 783156 | — |
Reaction Steps
123.0 g (0.96 mol) of 4-piperidinecarboxamide and 90.8 g (1.08 mol) of sodium bicarbonate are introduced under an argon atmosphere into 2 1 of dry toluene. 180.6 g, equivalent to 125.6 ml (1.056 mol), of bromomethylbenzene are added, and the mixture is heated under reflux for 5 h.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05096900 |
| Source dataset | uspto-grants-1992_03 |
| ORD ID | ord-41ef9a87cb5e42eab535d022bb0dbc2e |
| Source note | uspto-grants-1992_03 |