Ethanol → HCID 131716461, compound

HRID 2371970Notes

Reaction equation

HRID 2371970 reaction equation
[CH2:1]([C@@H:8]([CH2:17][C@H:18]([CH2:22][C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1)[C:19]([OH:21])=[O:20])[C:9]([NH:11][CH2:12][CH2:13][C:14]([OH:16])=[O:15])=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[Na:29][Na].[OH-].[Na+].C(O)C>CO.O>[Na+:29].[Na+:29].[CH2:1]([C@@H:8]([CH2:17][C@H:18]([CH2:22][C:23]1[CH:24]=[CH:25][CH:26]=[CH:27][CH:28]=1)[C:19]([OH:21])=[O:20])[C:9]([NH:11][CH2:12][CH2:13][C:14]([O-:16])=[O:15])=[O:10])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1.[CH2:1]([C@@H:8]([CH2:17][C@@H:18]([C:19]([OH:21])=[O:20])[CH2:22][C:23]1[CH:24]=[CH:25][CH:26]=[CH:27][CH:28]=1)[C:9]([NH:11][CH2:12][CH2:13][C:14]([O-:16])=[O:15])=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

6

Reactant 4

HCID 702EthanolHCID 14798Sodium HydroxideHCID 141233DisodiumHCID 14557664HCID 14557664, compound

Product 1

HCID 131716461HCID 131716461, compound

Reagents, catalysts & solvents 1

HCID 22242641Methanol--water (1/1)Solvent

Procedure

N-[(R*,R*-2,4-dibenzyl-4-carboxybutyryl]-3-aminopropionic acid, melting at 122°-124°. N-[(R*,R*)-2,4-dibenzyl-4-carboxybutyryl]-3-aminopropionic acid is converted to the disodium salt by the following procedure: To the solution of 0.38 g of the diacid in 25 ml of methanol:water (2:1) is added 2.0 ml of 1.00N sodium hydroxide. The solution is concentrated to give a solid. Ethanol is added and the suspension is concentrated and the solid is dried at 50° under high vacuum to yield the N-[(R*,R*)-2,4-dibenzyl-4-carboxybutyryl]-3-aminopropionic acid disodium salt.

Workup

  1. concentrationThe solution is concentrated
  2. customto give a solid
  3. concentrationthe suspension is concentrated
  4. customthe solid is dried at 50° under high vacuum

Sources & evidence

ORD record
ord-b0bdd14fbb4e4cd8970c5214139dc04e
Source dataset
uspto-grants-1992_03
Patent number
US05096925

Reaction notes

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