4-Methylbenzoyl Chloride → HCID 14366280, compound

HRID 2371984Notes

Reaction equation

HRID 2371984 reaction equation
[CH3:1][C:2]1[CH:10]=[CH:9][C:5]([C:6](Cl)=[O:7])=[CH:4][CH:3]=1.C[O:12][P:13]1(=O)[C:18]2[CH:19]=[CH:20][CH:21]=[CH:22][C:17]=2[C:16]2[CH:23]=[CH:24][CH:25]=[CH:26][C:15]=2[O:14]1>>[CH3:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([P:13]2(=[O:12])[C:18]3[CH:19]=[CH:20][CH:21]=[CH:22][C:17]=3[C:16]3[CH:23]=[CH:24][CH:25]=[CH:26][C:15]=3[O:14]2)=[O:7])=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 134054-Methylbenzoyl ChlorideHCID 11572319HCID 11572319, compound

Product 1

HCID 14366280HCID 14366280, compound

Conditions

Temperature
110 °C

Procedure

30.8 g (0.2 mol) of 4-methylbenzoyl chloride were warmed to 80° C. under a nitrogen atmosphere. 46 g (0.2 mol) of 6-methoxy-(6H)-dibenz[c,e][1,2]-oxaphosphorin 6-oxide were added dropwise over the course of 1 hour while stirring. The temperature was then slowly increased to 110° C. When the reaction was complete, the residue slowly crystallized out at room temperature. 60 g (90% of theory) of the abovementioned compound, which, after recrystallization from toluene, had a melting point of 124 to 125% C. were obtained.

Workup

  1. customthe residue slowly crystallized out at room temperature
  2. custom60 g (90% of theory) of the abovementioned compound, which, after recrystallization from toluene
  3. customwere obtained

Sources & evidence

ORD record
ord-7b2a82711f1d48b7b02ce9434a66c84f
Source dataset
uspto-grants-1992_03
Patent number
US05096935

Reaction notes

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