Acetic Anhydride → HCID 13565852, compound

HRID 2372069Notes

Reaction equation

HRID 2372069 reaction equation
[CH:1]1([NH:4][C:5]2[N:10]=[C:9]([N:11]3[CH2:16][CH2:15][N:14]([C:17]([O:19][CH2:20][CH3:21])=[O:18])[CH2:13][CH2:12]3)[C:8]([N+:22]([O-:24])=[O:23])=[CH:7][CH:6]=2)[CH2:3][CH2:2]1.[C:25](OC(=O)C)(=[O:27])[CH3:26]>C(O)(=O)C>[C:25]([N:4]([CH:1]1[CH2:3][CH2:2]1)[C:5]1[N:10]=[C:9]([N:11]2[CH2:16][CH2:15][N:14]([C:17]([O:19][CH2:20][CH3:21])=[O:18])[CH2:13][CH2:12]2)[C:8]([N+:22]([O-:24])=[O:23])=[CH:7][CH:6]=1)(=[O:27])[CH3:26]

Participants

4

Reactant 2

HCID 7918Acetic AnhydrideHCID 13565851Ethyl 4-[6-(cyclopropylamino)-3-nitro-2-pyridinyl]-1-piperazinecarboxylate

Product 1

HCID 13565852HCID 13565852, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

A solution of 64.0 g (0.19 mole) of 4-[6-(cyclopropylamino)-3-nitro-2-pyridinyl]-1-piperazinecarboxylic acid, ethyl ester, 115 ml of acetic anhydride and 115 ml of acetic acid was heated on a steam bath for 36 hours. The solvents were removed in vacuo, the residue was triturated with a mixture of ethanol and toluene which was also evaporated in vacuo to give 68.3 g of the title compound, mp 90-93° C.

Workup

  1. customThe solvents were removed in vacuo
  2. customthe residue was triturated with a mixture of ethanol and toluene which
  3. customwas also evaporated in vacuo

Sources & evidence

ORD record
ord-fed4f5553cfb47489ea24489bccbdd7b
Source dataset
uspto-grants-1992_03
Patent number
US05097032

Reaction notes

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