HCID 15052645, compound → HCID 15052644, compound

HRID 2372085Notes

Reaction equation

HRID 2372085 reaction equation
Cl[C:2]1[C:3]([F:22])=[C:4]([F:21])[C:5]([O:19][CH3:20])=[C:6]2[C:11]=1[N:10]([CH:12]1[CH2:14][CH2:13]1)[CH:9]=[C:8]([C:15]([OH:17])=[O:16])[C:7]2=[O:18].BrC1C(F)=C([F:43])C(OC)=C2C=1N(C1CC1)C=C(C(O)=O)C2=O.C1(N2C3C(=C(OC)C(F)=C(F)C=3C(F)(F)F)C(=O)C(C(O)=O)=C2)CC1.C1(N2C3C(=C(OC)C(F)=C(F)C=3)C(=O)C(C(O)=O)=C2)CC1>>[CH:12]1([N:10]2[C:11]3[C:6](=[C:5]([O:19][CH3:20])[C:4]([F:21])=[C:3]([F:22])[C:2]=3[F:43])[C:7](=[O:18])[C:8]([C:15]([OH:17])=[O:16])=[CH:9]2)[CH2:14][CH2:13]1

Participants

5

Reactant 4

HCID 15052645HCID 15052645, compoundHCID 15052646HCID 15052646, compoundHCID 15052647HCID 15052647, compoundHCID 19905745HCID 19905745, compound

Product 1

HCID 15052644HCID 15052644, compound

Procedure

In a similar manner, the following compounds were prepared: 8-chloro-1-cyclopropyl-6,7-difluoro-1,4-dihydro-5-methoxy-4-oxo-3-quinolinecarboxylic acid; 8-bromo-1-cyclopropyl-6,7-difluoro-1,4-dihydro-5-methoxy-4-oxo-3-quinolinecarboxylic acid; 1-cyclopropyl-6,7-difluoro-8-trifluoromethyl-5-methoxy-4-oxo-3-quinolinecarboxylic acid; and 1-cyclopropyl-6,7-difluoro-1,4-dihydro-5-methoxy-4-oxo-3-quinolinecarboxylic acid.

Workup

  1. customIn a similar manner, the following compounds were prepared

Sources & evidence

ORD record
ord-a9e5cdd875194510a50291b58b674df6
Source dataset
uspto-grants-1992_03
Patent number
US05097032

Reaction notes

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