HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 2-Chloro-4-(ethanesulfonyl)-3-hydroxybenzoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 2,3-Dichloro-4-(ethanesulfonyl)benzoic acid | HCID 2764249 | — |
| Product | 2-Chloro-4-(ethanesulfonyl)-3-hydroxybenzoic acid | HCID 14745485 | — |
Reaction Steps
A solution of the 4-ethylsulfonyl-2,3-dichlorobenzoic acid prepared in Example 3 (0.35 mole) in 500 ml of 20% sodium hydroxide was heated at reflux for 7 hours. After cooling, the aqueous solution was acidified with concentrated hydrochloric acid and extracted twice with ethyl acetate. The ethyl acetate extracts were combined, dried over magnesium sulfate, and concentrated in vacuo to afford the crude acid. Recrystallization of the crude acid from ethyl acetate afforded the desired pure acid as white crystals. m.p. 188°-192° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05097068 |
| Source dataset | uspto-grants-1992_03 |
| ORD ID | ord-05d1ce9333b14585a6e85de674ce586b |
| Source note | uspto-grants-1992_03 |