Hydrochloric Acid → HCID 11066039, compound

Participants

Reaction Steps

In a three-necked flask of 50 ml in internal volume which was well dried under reduced pressure in nitrogen stream were charged 20 ml of methylene chloride, 3.57 g (13.0 mmol) of the above alcohol (3) and 1.20 ml (16.9 mmol) of acetyl chloride and then 1.37 ml (16.9 mmol) of pyridine was added thereto under ice-cooling, followed by stirring at room temperature overnight. The reaction was stopped by adding 1N aqueous hydrochloric acid solution and the reaction mixture was extracted with methylene chloride and dried over anhydrous magnesium sulfate. Solvent was distilled off to obtain a crude product, which was purified by silica gel column chromatography to obtain the above acetate (4).

Provenance & Evidence