Morpholine → HCID 53695518, compound

HRID 2372171Notes

Reaction equation

HRID 2372171 reaction equation
[C:1]([C:4]1[N:12]=[CH:11][CH:10]=[CH:9][C:5]=1[C:6](Cl)=O)(=[O:3])[CH3:2].[NH:13]1[CH2:18][CH2:17][O:16][CH2:15][CH2:14]1>>[C:1]([C:4]1[N:12]=[CH:11][CH:10]=[CH:9][C:5]=1[CH2:6][N:13]1[CH2:18][CH2:17][O:16][CH2:15][CH2:14]1)(=[O:3])[CH3:2]

Participants

3

Reactant 2

HCID 8083MorpholineHCID 54278891HCID 54278891, compound

Product 1

HCID 53695518HCID 53695518, compound

Procedure

Following the procedures of Example 14, 2-acetylnicotinic acid chloride (1.0 g, 5.5 mmol) and morpholine (0.6 g, 6.7 mmol) are reacted together to give 4-(2-acetylnicotinyl)morpholine, which compound (1.0 g, 4.2 mmol) is then reacted with 4-(3-fluorophenyl)semicarbazide (0.7 g, 4.2 mmol) to give 4-(2-acetylnicotinyl)morpholine 4-(3-fluorophenyl)semicarbazone, m.p. 193°-195° compound 150).

Workup

  1. customare reacted together

Sources & evidence

ORD record
ord-b5a487d367514dcb90aca9f7504cdffc
Source dataset
uspto-grants-1992_03
Patent number
US05098462

Reaction notes

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